9:30 - 11:35

Slot 1
Chairman: Ali MADANI, General Manager, AVICENNE DEVELOPPEMENT

Market Strategy and Contract manufacturing issues

Worldwide Orthopaedic Market and Contract manufacturing strategy

- Hip, Knee, Spine Trauma, Orthobiologics and dental Implants markets and trends
- Contract manufacturing market Vs In house manufacturing
- The Major and Challenger strategies
- Risks and Limits

The changing regulatory landscape and implications for medical device manufacturers

Building a leading edge worldclass medical contractor

- Build up process
- Outstanding points

Helping the development of our customers in the light of the globalisation of orthopaedic markets. A new challenge for contract manufacturers!

11:35 - 14:00

Networking lunch

14:00 - 16:05

Slot 2
Chairman: Daniel DELFOSSE, Vice President Innovation & Technology, MATHYS

Innovation in Products and Materials and Tribology

Technical factors from the largest MoM retrieval database globally

- Implant failure mechanisms
- Mal-orientation
- Edge loading

The Potential of Nanotechnology in Orthopaedics

- Nanotechnology enhanced implant surfaces modify the cellular and bacterial reaction and enhance osseointegration as well as preventing infection
- Nanoparticles and Carbon Nanotubes have been shown to enhance the mechanical resistance of most biomaterials
- Nanotechnology is an expanding opportunity for the orthopaedic industry to enhance existing implant’s performance and also allows for new applications

First clinical results with vitamin-doped cross-linked polyethylene

- Hype or hope for vitamin-doped polyethylene?
- Improved wear and longterm stability
- Innovation based on material development

Biomaterials in interaction with Cartilage

- Proposition for cartilage friendly biomaterials
- Assessment of cartilage friendliness
- Presentation of results

Tribology of Different Bearings for Artificial Hip Joints

- Importance of tribology
- Advantages and disadvantages of different bearings
- Future developments

16:05 - 16:50

Networking coffee break

16:50 - 18:30

Two Parallel Slots

Slot 3
Chairman: Bernard MASSON, Special Advisor, CERAMTEC MEDICAL PRODUCTS

Raw Materials and Ceramics

Corrosion: still an issue?

- Recent improvements have been made in the field of stainless steels which offer tremendous properties.
- Examples of X15TN, used today for drills, cutting tools… and MX466 a precipitation hardening grade capable of very high strength combined with good toughness will be given

Understanding implantable grade PEEK’s interface and interaction with cells

- Increasing use of PEEK biomaterial (over 2.5m devices) in contact with tissue
- Tailoring the tissue response may be achieved through modifying versatile PEEK through addition of compounds (eg. HA) or surface modifications
- Discussing this growing interest areas and examining some examples that interact or interface with human and bacterial cells.

Ceramics in Implantology: History and Future

- Load bearing ceramics
- Implantology in orthopaedics and dental
- Restaurative application of bioceramics

Evolution of ceramics in Orthopaedics

- The main technological stages
- Worldwide ceramics market trends
- Future applications

Slot 4
Chairman: Ali MADANI, General Manager, AVICENNE DEVELOPPEMENT

Coating

Design requirements for coated implants

Innovation in Biomedical Coatings

- Advanced Sponge Plasma Spray Coating to enhance the bone ingrowth
- Coatings development for innovative substrates
- Eurocoating management of Plasma Spray and other innovative technologies (e.g. Rapid Manufacturing) with a "customer-oriented" philosophy to support our customer products development

The coated implants of the future are ready now

- Overview of the medical coating industry evolution
- New generation of tough ceramic coatings
- VPS coatings on PEEK substrates
- Multifunctional bio-resorbable coatings with biofilm inhibition and optimal implant fixation

18:30 - 20:00

Cocktail on Exhibition Hall

9:00 - 10:40

Two Parallel Slots

Slot 5
Chairman: Tim LAWTON, Director, C-REG MEDICAL

Regulatory, Certification and Pricing issues

Update on French legislation on medical devices

- Modification on the law relating to clinical trials,
- Legal consequences of the Directive 2007/47,
- Reimbursement of medical devices (T2A / LPP / GHS),
- Product liability recent case-laws

Will the changes introduced by 2007/47 and the new allocation of medical devices to the Directorate General Health and Consumer protection affect this sector?

- Regulatory developments at European level: the recast
- Advanced therapies and combination products
- Revision surgery

FDA, is it worth it to make the effort

- Changing face of the FDA, how does it effect an European PME
- The FDA submission is one thing, but what about the rest?
- As an European manufacturer, should we still keep control of the FDA
submission?

Obtaining Medical Device Reimbursement Within the United States

- The role of the Food and Drug Administration (FDA) in device approval
- Understanding the Centers for Medicare and Medicaid (CMS) and how this affects reimbursement
- Developing a strategy for reimbursement, considering national versus regional approaches and private insurers

Slot 6
Chairman: François ORY, President, FORECREU BIOMETAL

Processing, Finishing, Marking & Cleaning

Processing cannulated bars for trauma applications

- Processing stainless and titanium into cannulated bars
- Improved features and properties
- Time to market and economics from the customer point of view

Process Innovation in Vibratory Finishing of implants - Drag Grinding Techniques for high ambitious surfaces

- Machine Systems
- Process Technology
- Environmental Aspects

High Precision Cleaning Processes

- Cleaning and surface preparation
- Approve processes
- Wastewater treatment

Advanced histopathology for bone implants

- Tissular exploration of the performance of bone implant needs adequate tools
- Beside ISO standards, proposition of innovative approaches to add value to the outcome of your products is discussed

10:40 - 11:10

Networking coffee break

11:10 - 12:30

Slot 7
Chairman: Thomas NYDEGGER, Manager Spine Research EMEA, ZIMMER GmbH

Spine, Trauma and Orthobiologics

The SpineJack® Implant: An innovation in treating Vertebral Compression Fractures

- About the Implant
- Clinical Tests and Results
- About VEXIM, SAS

Introduction to dynamic stabilization of the spine

- The function of the components of a dynamic stabilization device for the spine
- Materials used and their properties
- Long term bio-stability of the used polymers

Postition of Orthobiologics in Spine for Western Europe

- Current positioning of orthobiologics
- Classifications and trends
- Drug & device combinations in Spine
- Future market for othobiologics

12:30 - 14:15

Networking lunch

14:15 - 15:30

Slot 8
Chairman: Christophe PILLOT, Senior Consultant, AVICENNE DEVELOPPEMENT

Manufacturing Implants and Surgical Instrumentation

Considerations to becoming a true global material supplier to the orthopedic market

- What are they key areas of focus for today’s OEMs and CMs?
- What are they key areas of focus for today’s raw material suppliers?
- How do we merge these needs to develop successful long-term products?

Automated polishing of the femurs

- Presentation of the company AESCULAP SAS Chaumont: history & key figures
- Description of the automated polishing process
- Performance (Quantity per day, alteration rate)

Existing solutions for Single use medical devices in thermoplastics

- Status of our Hip Rasps.
- Advantage and inconvenience
- Development in progress and future application

Manufacturing Implants, Instruments, cases, others where is the cash cow?

- Orthopaedic supply chain trends
- Success key for contract manufacturers?
- Contract manufacturing risks & limits
- Prospective, main challenge for 2020

> Profil des visiteurs :

Les visiteurs sur IMPLANTS sont des acheteurs ou responsables de socétés orthopédiques, des fabricants ou sous-traitants d'implants :

- Chief Executive Officers
- Chief Financial Officers
- Chief Operations Officers
- Managing Directors
- Sales managers
- Marketing Directors
- Production Managers
- Purchasing Directors
- Export Directors
- Development Managers Knee
- Development Managers Hip
- Development managers Spine
- R&D managers
- Director Strategic sourcing
- Product managers Knee
- Product managers Hip
- Product Managers Spine
- Business Developpement Directors
- Business Intelligence

Lyon, l' "Implants Valley“ française, à proximité immédiate de l'Italie, la Suisse et l'Allemagne :